多个小组对大脑进行了成像，结果表明在人类中表现出类似镜像神经元活性的大脑区域类似于猕猴中含有镜像神经元的大脑区域。 有趣的是，在布罗卡地区也发现了镜像神经元，该区域负责语言的产生，尽管这引起了很多争论。 这种神经影像学证据似乎很有希望。 但是，由于在实验过程中并未直接探测单个神经元，因此即使将成像的大脑区域与猴子发现的大脑区域非常相似，也很难将这种大脑活动与人脑中的特定神经元相关联。 根据研究人类镜像神经元系统的研究人员Christian Keysers的说法，大脑扫描的一小部分区域可以对应数百万个神经元。 因此，无法将人类发现的镜像神经元与猴子发现的镜像神经元直接进行比较，以确认系统是否相同。
Multiple groups have imaged the brain and found that brain regions that exhibit activity similar to mirror neurons in humans are similar to brain regions in the macaque that contain mirror neurons. Interestingly, mirror neurons were also found in the Broca region, which is responsible for language production, although this has caused much controversy. This neuroimaging evidence seems promising. However, since a single neuron is not directly detected during the experiment, even if the imaged brain region is very similar to the brain region found by the monkey, it is difficult to correlate this brain activity with a specific neuron in the human brain. According to Christian Keysers, a researcher on the human mirror neuron system, a small portion of the brain scan can correspond to millions of neurons. Therefore, it is impossible to directly compare the mirror neurons found by humans with the mirror neurons found by monkeys to confirm whether the systems are identical.